Yes, but it may not work for some particular transactions (maybe because of a bug in pybtctool), when the address isn’t in the local instance of Bitcoin Core.
The transaction should be signed manually (e.g. with the pybtc CLI tool, or any other way - for example using another utility such as https://github.com/lian/bitcoin-ruby (for Ruby developers)).
One tool that’s been reported to work well is bitcoinjs-lib.
Reference